Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 9/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | PKM | P14618 | 5/20 | 0.66 |
| ▸ | STAT3 | P40763 | 9/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28577822 | 0.88 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL25063113 | 0.87 | STAT3 (0.58) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL22680776 | 0.80 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL12974167 | 0.79 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL28571041 | 0.78 | STAT3 (0.77) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL25063120 | 0.78 | STAT3 (0.57) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL2681128 | 0.78 | STAT3 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL881749 | 0.78 | STAT3 (0.77) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL1804666 | 0.77 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL28573043 | 0.77 | MEN1 (0.75) | NPC1RAB9AMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456980-A | Application of thiazole compounds in preparation of medicines for treating and preventing cancers | 北京大学 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022206084-A1 | USE OF THIAZOLE COMPOUND IN PREPARATION OF DRUG FOR TREATING AND PREVENTING CANCER | 北京大学 | 2022-10-06 | — | — | WO | disclosed |
| CN-112957358-A | Application of nitazoxanide and derivatives thereof in preparing medicines for preventing and treating bone destructive diseases | 北京大学第三医院（北京大学第三临床医学院） | 2021-06-15 | — | — | CN | disclosed |