Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19348159 | 0.82 | FOLH1 (0.59) | FOLH1TSHRALDH1A1ALOX15GRIK1 | |
| SCHEMBL8470980 | 0.78 | FOLH1 (0.50) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL8470973 | 0.78 | FOLH1 (0.50) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL8447505 | 0.77 | FOLH1 (0.49) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL30365583 | 0.76 | FOLH1 (0.76) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL70392 | 0.76 | FOLH1 (0.76) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL27983622 | 0.76 | SCN1A (0.53) | FOLH1ALDH1A1 | |
| SCHEMBL20005917 | 0.75 | CYP3A4 (0.45) | — | |
| SCHEMBL8727361 | 0.75 | FOLH1 (0.46) | FOLH1TSHRALDH1A1ALOX15MAPT | |
| SCHEMBL28563429 | 0.75 | FOLH1 (0.46) | FOLH1TSHRALDH1A1ALOX15HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112867722-A | MACROCYCLIC SPIROETHERS (MACROCYCLIC SPIROETHERS) as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2021-05-28 | — | — | CN | disclosed |