Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.79 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.79 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.79 |
| ▸ | KDR | P35968 | 9/20 | 0.73 |
| ▸ | FLT3 | P36888 | 3/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28582694 | 1.00 | FGFR1 (0.79) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28575313 | 1.00 | FGFR1 (0.79) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28562982 | 0.95 | FGFR1 (0.87) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28569401 | 0.95 | FGFR1 (0.87) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28563004 | 0.95 | FGFR1 (0.87) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28574037 | 0.95 | FGFR1 (0.87) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28574024 | 0.93 | FGFR1 (0.91) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28572355 | 0.93 | FGFR1 (0.91) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL28580331 | 0.93 | FGFR1 (0.91) | FGFR1HDAC1FGFR2FGFR4FGFR3 | |
| SCHEMBL29400862 | 0.93 | FGFR1 (0.91) | FGFR1HDAC1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920167-B | Double-target inhibitor targeting FGFR and HDAC, preparation method and application thereof, pharmaceutical composition and medicament | 四川大学华西医院 | 2022-08-26 | — | — | CN | disclosed |
| CN-112920167-A | Double-target inhibitor targeting FGFR and HDAC, preparation method and application thereof, pharmaceutical composition and medicament | 四川大学华西医院 | 2021-06-08 | — | — | CN | disclosed |