Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 11/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.61 |
| ▸ | NPC1 | O15118 | 10/20 | 0.61 |
| ▸ | RAB9A | P51151 | 10/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29057176 | 0.90 | STAT3 (0.59) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17666851 | 0.85 | STAT3 (0.59) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17666852 | 0.85 | STAT3 (0.59) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28577822 | 0.82 | NPC1 (0.64) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17677414 | 0.81 | NPC1 (0.67) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28315193 | 0.81 | KMT2A (0.61) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL25063120 | 0.80 | STAT3 (0.57) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29056922 | 0.80 | STAT3 (0.77) | STAT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11154311 | 0.78 | STAT3 (0.79) | STAT3MEN1KMT2ANPC1RAB9A | |
| Tizoxanide SCHEMBL375440 | 0.77 | STAT3 (1.00) | STAT3MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112957358-A | Application of nitazoxanide and derivatives thereof in preparing medicines for preventing and treating bone destructive diseases | 北京大学第三医院（北京大学第三临床医学院） | 2021-06-15 | — | — | CN | disclosed |