Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tempol Hydroxylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tempol Hydroxylamine SCHEMBL27621676 | 1.00 | GAA (0.34) | GAAL3MBTL1KDM4EPAOXKMT2A | |
| Tempol Hydroxylamine SCHEMBL3946306 | 0.92 | GAA (0.39) | GAAL3MBTL1KDM4EKMT2ACA12 | |
| Tempol Hydroxylamine SCHEMBL2867127 | 0.89 | GAA (0.39) | GAAL3MBTL1KDM4EKMT2AALOX15 | |
| Acetic Acid SCHEMBL27621684 | 0.84 | KDM4E (0.43) | GAAKDM4EPAOXKMT2AALOX15 | |
| Acetic Acid SCHEMBL2864226 | 0.84 | KDM4E (0.43) | GAAKDM4EPAOXKMT2AALOX15 | |
| Tempol Hydroxylamine SCHEMBL986355 | 0.83 | GAA (0.46) | GAAL3MBTL1KDM4EKMT2AALOX15 | |
| Tempol Hydroxylamine SCHEMBL7143560 | 0.81 | S1PR2 (0.39) | GAAL3MBTL1KDM4ELMNAALDH1A1 | |
| SCHEMBL27648896 | 0.80 | GAA (0.45) | GAAL3MBTL1KDM4EPAOXKMT2A | |
| Tempol Hydroxylamine SCHEMBL3938500 | 0.79 | GAA (0.46) | GAAL3MBTL1 | |
| Acetic Acid SCHEMBL2857385 | 0.78 | PAOX (0.33) | GAAPAOXKMT2ACA12CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499286-B1 | STABILIZED BODY CARE PRODUCTS AND HOUSEHOLD PRODUCTS | BASF SE (DE) | 2010-04-07 | — | — | EP | claimed |
| EP-1954457-B1 | COLOR STABILIZATION OF CORK AND COLORED WOODS BY THE COMBINED USE OF INORGANIC AND ORGANIC UV-ABSORBERS | CIBA HOLDING INC (CH) | 2009-04-15 | — | — | EP | claimed |
| EP-1362083-A1 | INK-JET INK AND RECORDING MATERIAL | Ciba SC Holding AG (CH) | 2003-11-19 | — | — | EP | claimed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | claimed |
| EP-1230276-B1 | PHOTOINITIATOR FORMULATIONS | CIBA SC HOLDING AG (CH) | 2005-12-14 | — | — | EP | disclosed |
| US-6803392-B1 | AQUEOUS, STORAGE-STABLE, NON- SEDIMENTING SUSPENSIONS COMPRISING AT LEAST ONE MONO- OR BIS-ACYLPHOSPHINE OXIDE | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-10-12 | — | — | US | disclosed |
| EP-1362083-A1 | INK-JET INK AND RECORDING MATERIAL | Ciba SC Holding AG (CH) | 2003-11-19 | — | — | EP | disclosed |
| EP-1230276-A1 | PHOTOINITIATOR FORMULATIONS | Ciba SC Holding AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | disclosed |
| WO-2001029093-A1 | PHOTOINITIATOR FORMULATIONS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-04-26 | — | — | WO | disclosed |