SCHEMBL28580233

SCHEMBL28580233

O=C[C@@H]1CC[C@H]1OC(=O)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.48
CHRM4 P08173 2/20 0.48
CHRM1 P11229 2/20 0.48
CHRM3 P20309 2/20 0.48
CHRNA7 P36544 2/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
SLC18A3 Q16572 1/20 0.45
HTR3E A5X5Y0 2/20 0.44
HTR3B O95264 2/20 0.44
HTR3A P46098 2/20 0.44
HTR3D Q70Z44 2/20 0.44
HTR3C Q8WXA8 2/20 0.44
BCHE P06276 1/20 0.43
APOBEC3A P31941 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28563858 0.78 BCHE (0.44) MEN1KMT2ABCHE
SCHEMBL27987999 0.77 CHRM2 (0.51) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL1785360 0.77 SLC18A3 (0.61) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL25755470 0.77 SLC18A3 (0.61) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL26710051 0.77 SLC18A3 (0.61) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL10907426 0.77 SLC18A3 (0.61) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL11383894 0.76 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL11376280 0.76 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL11384911 0.76 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3CHRNA7
SCHEMBL11373840 0.76 CHRM2 (0.50) CHRM2CHRM4CHRM1CHRM3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112867722-B MACROCYCLIC SPIROETHERS (MACROCYCLIC SPIROETHERS) as MCL-1 inhibitors 苏州亚盛药业有限公司 2022-09-23 CN disclosed
CN-112867722-A MACROCYCLIC SPIROETHERS (MACROCYCLIC SPIROETHERS) as MCL-1 inhibitors 苏州亚盛药业有限公司 2021-05-28 CN disclosed