Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.48 |
| ▸ | INSR | P06213 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28566165 | 0.87 | LRRK2 (0.52) | LRRK2PTK2INSRIGF1RALK | |
| SCHEMBL28563009 | 0.86 | LRRK2 (0.60) | LRRK2PTK2INSRIGF1RALK | |
| SCHEMBL28913878 | 0.82 | PTK2 (0.57) | PTK2INSRIGF1RALKMAP4K1 | |
| SCHEMBL28913875 | 0.82 | PTK2 (0.57) | PTK2INSRIGF1RALKMAP4K1 | |
| SCHEMBL9285147 | 0.82 | LRRK2 (0.81) | LRRK2MAP3K14 | |
| SCHEMBL15528286 | 0.80 | LRRK2 (1.00) | LRRK2MAP3K14 | |
| SCHEMBL5021250 | 0.80 | LRRK2 (0.80) | LRRK2MAP3K14 | |
| SCHEMBL28580349 | 0.79 | PTK2 (0.59) | PTK2INSRIGF1RALKMAP4K1 | |
| SCHEMBL28569396 | 0.77 | ALK (0.64) | PTK2INSRIGF1RALKMAP4K1 | |
| SCHEMBL28564190 | 0.77 | EGFR (0.64) | LRRK2PTK2INSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-A | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2021-05-07 | — | — | CN | disclosed |