Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | BRAF | P15056 | 4/20 | 0.64 |
| ▸ | ABL1 | P00519 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851380 | 0.86 | BRAF (0.57) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL2857476 | 0.85 | KDR (0.49) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL3512003 | 0.82 | BRAF (0.54) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL2853422 | 0.81 | KDR (0.78) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL2858538 | 0.81 | BRAF (0.70) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL2855524 | 0.81 | BRAF (0.82) | KDRBRAFABL1DYRK1A | |
| SCHEMBL2854256 | 0.80 | BRAF (0.79) | KDRBRAFCYP2C9 | |
| SCHEMBL2855450 | 0.80 | BRAF (0.72) | KDRBRAFABL1 | |
| SCHEMBL13184957 | 0.79 | BRAF (0.69) | KDRBRAFABL1PDGFRBBCR | |
| SCHEMBL2861968 | 0.79 | BRAF (1.00) | KDRBRAFABL1PDGFRBBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |