⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523813 | 0.93 | CA1 (0.30) | — | |
| SCHEMBL550470 | 0.93 | CA1 (0.34) | — | |
| SCHEMBL14167644 | 0.91 | — | — | |
| SCHEMBL9934016 | 0.89 | CA1 (0.34) | — | |
| SCHEMBL320835 | 0.86 | — | — | |
| SCHEMBL18279897 | 0.84 | — | — | |
| SCHEMBL550678 | 0.82 | CA1 (0.30) | — | |
| SCHEMBL4071457 | 0.82 | — | — | |
| SCHEMBL11202375 | 0.78 | — | — | |
| SCHEMBL3958845 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893069-B2 | Substituted imidazo[2,1-b]thiazole compounds and uses thereof | GRUENENTHAL GMBH (DE) | 2011-02-22 | — | — | US | claimed |
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |
| US-20070249631-A1 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2007-10-25 | — | — | US | claimed |
| US-11135228-B2 | Cysteinyl-proresolving mediators that promote resolution of infection and organ protection | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | GRUENENTHAL GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| US-20170258806-A1 | OXYLIPIN-PEPTIDE CONJUGATED MEDIATORS THAT PROMOTE RESOLUTION OF INFECTION, ORGAN PROTECTION AND TISSUE REGENERATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-09-14 | — | — | US | disclosed |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
| US-20140199316-A1 | METHODS OF TREATING COMPLICATIONS AND DISORDERS ASSOCIATED WITH G-CSF ADMINISTRATION | SACKSTEIN ROBERT (US) | 2014-07-17 | — | — | US | disclosed |
| US-8765126-B2 | Methods of treating complications and disorders associated with G-CSF administration | SACKSTEIN ROBERT (US) | 2014-07-01 | — | — | US | disclosed |
| US-20130224217-A1 | METHODS OF TREATING COMPLICATIONS AND DISORDERS ASSOCIATED WITH G-CSF ADMINISTRATION | SACKSTEIN ROBERT (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2012151576-A1 | METHODS OF TREATING COMPLICATIONS AND DISORDERS ASSOCIATED WITH G-CSF ADMINISTRATION | SACKSTEIN ROBERT (US) | 2012-11-08 | — | — | WO | disclosed |
| US-7425560-B2 | Thioxanthine derivatives as myeloperoxidase inhibitors | ASTRAZENECA AB (SE) | 2008-09-16 | — | — | US | disclosed |
| US-7420056-B2 | Substituted bicyclic imidazo-3-ylamine compounds | GRUENENTHAL GMBH (DE) | 2008-09-02 | — | — | US | disclosed |
| US-20080076802-A1 | VINYLAMINOPYRAZOLE DERIVATIVES AS PESTICIDES | MERIAL, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20070249631-A1 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2007-10-25 | — | — | US | disclosed |
| US-20070155965-A1 | SUBSTITUTED BICYCLIC IMIDAZO-3-YLAMINE COMPOUNDS | GRUENENTHAL GMBH. (DE) | 2007-07-05 | — | — | US | disclosed |
| US-20070032468-A1 | Novel thioxanthine derivatives for use as inhibitors of mpo | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| WO-2005111676-A1 | OPTICAL FILM, OPTICAL COMPENSATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY UNIT AND SELF LUMINOUS DISPLAY UNIT | FUJIFILM CORPORATION (JP) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005111675-A1 | OPTICAL COMPENSATION POLARIZING PLATE, IMAGE DISPLAY UNIT AND LIQUID CRYSTAL DISPLAY UNIT | FUJIFILM CORPORATION (JP) | 2005-11-24 | — | — | WO | disclosed |
| US-20050234036-A1 | Thioxanthine derivatives as myeloperoxidase inhibitors | ASTRAZENECA AB (SE) | 2005-10-20 | — | — | US | disclosed |