Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 11/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587082 | 0.92 | PTK2 (0.61) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28572359 | 0.89 | ALK (0.61) | PTK2ALKINSRIGF1RNUAK1 | |
| SCHEMBL28571162 | 0.83 | EGFR (0.68) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28566195 | 0.81 | EGFR (0.57) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28574074 | 0.81 | PTK2 (0.72) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28577110 | 0.79 | PTK2 (0.60) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28568480 | 0.79 | PTK2 (0.47) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL22595131 | 0.79 | EGFR (0.48) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL22595127 | 0.77 | NUAK1 (0.44) | PTK2ALKINSRIGF1REGFR | |
| SCHEMBL28562993 | 0.77 | PTK2 (0.62) | PTK2ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-B | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-112771032-A | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2021-05-07 | — | — | CN | disclosed |