SCHEMBL2858463

SCHEMBL2858463

Cc1cc2cc(N)ccc2[nH]1.Cn1ccc2c(N)cccc2c1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.54
KEAP1 Q14145 1/20 0.54
PARP1 P09874 3/20 0.43
EGFR P00533 1/20 0.39
BRD4 O60885 2/20 0.39
GAA P10253 3/20 0.38
MAPT P10636 4/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1B1 Q16678 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HRH4 Q9H3N8 1/20 0.36
TP53 P04637 1/20 0.35
PRKCI P41743 1/20 0.35
LMNA P02545 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30098515 0.78 GAA (0.56) KEAP1PARP1BRD4GAAMAPT
SCHEMBL564816 0.78 GAA (0.56) KEAP1PARP1BRD4GAAMAPT
SCHEMBL397246 0.73 CYP2A6 (1.00) CYP2A6KEAP1EGFRGAAMAPT
Hydrochloric Acid SCHEMBL11614276 0.72 CYP2A6 (0.96) CYP2A6KEAP1EGFRGAAMAPT
SCHEMBL23346719 0.68 PRKCI (0.56) EGFRBRD4GAAHPGDKDM4E
SCHEMBL11086335 0.65 CYP2A6 (0.62) CYP2A6KEAP1EGFRGAAMAPT
SCHEMBL16455687 0.65 PRKCI (0.52) CYP2A6EGFRBRD4GAAMAPT
SCHEMBL13833580 0.64 GAA (0.57) CYP2A6BRD4GAAMAPTCYP1A2
SCHEMBL30349871 0.63 PARP1 (0.53) KEAP1PARP1BRD4HPGDKDM4E
SCHEMBL25405559 0.63 PARP1 (0.53) KEAP1PARP1BRD4HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2142503-A2 PROCESS FOR THE MANUFACTURE FOR NON-STEROIDAL ANTI-INFLAMMATORY AGENTS AND INTERMEDIATES THEREOF Intendis GmbH (DE) 2010-01-13 EP disclosed
WO-2008128750-A2 PROCESS FOR THE MANUFACTURE FOR NON-STEROIDAL ANTI-INFLAMMATORY AGENTS AND INTERMEDIATES THEREOF INTENDIS GMBH (DE) 2008-10-30 WO disclosed