Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.75 |
| ▸ | AURKA | O14965 | 4/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.75 |
| ▸ | KIT | P10721 | 4/20 | 0.75 |
| ▸ | FLT1 | P17948 | 4/20 | 0.75 |
| ▸ | BRAF | P15056 | 2/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293200 | 0.86 | KDR (1.00) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4293486 | 0.86 | KDR (0.72) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4288568 | 0.86 | KDR (0.74) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4293783 | 0.86 | KDR (0.78) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4280488 | 0.86 | KDR (0.74) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4290485 | 0.86 | KDR (0.79) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL2857640 | 0.86 | KDR (0.66) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4295745 | 0.85 | KDR (0.78) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4293007 | 0.85 | KDR (0.71) | KDRAURKAPDGFRBKITFLT1 | |
| SCHEMBL4289991 | 0.85 | KDR (0.71) | KDRAURKAPDGFRBKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |