Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.42 |
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862498 | 0.96 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| SCHEMBL13528909 | 0.96 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| SCHEMBL2853813 | 0.96 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| Formic Acid SCHEMBL2858552 | 0.93 | CHRNA7 (0.42) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| Formic Acid SCHEMBL2852294 | 0.91 | CHRNA7 (0.42) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| Formic Acid SCHEMBL2857648 | 0.89 | GSK3B (0.48) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| Formic Acid SCHEMBL2859293 | 0.89 | GSK3B (0.48) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| Formic Acid SCHEMBL2861542 | 0.89 | GSK3B (0.48) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| SCHEMBL2851370 | 0.89 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 | |
| SCHEMBL2851368 | 0.89 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-B1 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS-RELATED DISEASES | MEMORY PHARM CORP (US) | 2010-01-20 | — | — | EP | claimed |