Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320202 | 0.94 | USP2 (0.47) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA | |
| SCHEMBL22323275 | 0.85 | USP2 (0.41) | USP2SMN1; SMN2EPHX2HPGDALOX15 | |
| SCHEMBL6749647 | 0.83 | USP2 (0.43) | USP2SMN1; SMN2HPGDALOX15TSHR | |
| SCHEMBL4980253 | 0.83 | USP2 (0.38) | USP2SMN1; SMN2EPHX2HPGDALOX15 | |
| SCHEMBL24442411 | 0.81 | USP2 (0.46) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA | |
| SCHEMBL27388627 | 0.79 | USP2 (0.62) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA | |
| SCHEMBL1086226 | 0.79 | USP2 (0.47) | USP2SMN1; SMN2EPHX2HPGDALOX15 | |
| SCHEMBL31191651 | 0.79 | USP2 (0.42) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA | |
| SCHEMBL1709866 | 0.79 | USP2 (0.50) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA | |
| SCHEMBL6914295 | 0.79 | USP2 (0.50) | USP2SMN1; SMN2EPHX2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778299-B | Piperazine ureido derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-112778299-A | Piperazine ureido derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-05-11 | — | — | CN | disclosed |