Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CMA1 | P23946 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | CTRC | Q99895 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25054148 | 1.00 | ACE (0.66) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL21409190 | 0.92 | KLK5 (0.62) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL21409192 | 0.92 | KLK5 (0.62) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL21409191 | 0.92 | KLK5 (0.62) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL22962169 | 0.92 | ACE (0.67) | ACELMNACMA1F2PRSS1 | |
| SCHEMBL29046823 | 0.90 | ACE (0.64) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL29046826 | 0.90 | ACE (0.64) | ACELMNACMA1SMN1; SMN2F2 | |
| SCHEMBL3692085 | 0.90 | ACE (0.77) | ACECMA1F2PRSS1KLK5 | |
| SCHEMBL3692081 | 0.90 | ACE (0.77) | ACECMA1F2PRSS1KLK5 | |
| SCHEMBL22409423 | 0.90 | ACE (0.77) | ACECMA1F2PRSS1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | disclosed |