Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 4/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.41 |
| ▸ | TNF | P01375 | 3/20 | 0.41 |
| ▸ | IL1B | P01584 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23915922 | 1.00 | CRBN (0.55) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL30170797 | 0.94 | CRBN (0.49) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL28584135 | 0.88 | CRBN (0.65) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL23915841 | 0.88 | CRBN (0.65) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL23806442 | 0.84 | CRBN (0.61) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL24269118 | 0.84 | CRBN (0.61) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL22511566 | 0.84 | CRBN (0.61) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL24132316 | 0.82 | CRBN (0.58) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL23945328 | 0.82 | CRBN (0.58) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL24269120 | 0.79 | CRBN (0.65) | CRBNDDB1IKZF1IKZF3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-115697989-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-112888681-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2021-06-01 | — | — | CN | disclosed |