Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259890 | 0.83 | KDM4E (0.40) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL474339 | 0.83 | CYP1A2 (0.55) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL29798837 | 0.83 | CYP1A2 (0.55) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30293270 | 0.80 | CYP1A2 (0.53) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL5143886 | 0.73 | CYP1A2 (0.47) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13838140 | 0.73 | CYP1A2 (0.47) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL19117688 | 0.73 | CYP1A2 (0.47) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL5966706 | 0.73 | CYP1A2 (0.47) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL627253 | 0.73 | CYP1A2 (0.47) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL1520214 | 0.73 | ERCC1 (0.66) | CYP1A2ERCC1FEN1ERCC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530239-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-115697989-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-112888681-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2021-06-01 | — | — | CN | disclosed |