Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.78 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | SGK1 | O00141 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28605050 | 0.89 | MAP4K1 (0.71) | MAP4K1TNIKPAK1PKN1MAP3K11 | |
| SCHEMBL28600335 | 0.88 | MAP4K1 (0.61) | MAP4K1TNIKPAK1PKN1MAP3K11 | |
| SCHEMBL28597666 | 0.86 | MAP4K1 (0.73) | MAP4K1TNIKPAK1PKN1MAP3K11 | |
| SCHEMBL21592527 | 0.84 | MAP4K1 (0.63) | MAP4K1TNIKMAP3K11SGK1IL2 | |
| SCHEMBL28605062 | 0.82 | MAP4K1 (0.65) | MAP4K1TNIKPIK3CG | |
| SCHEMBL21592926 | 0.82 | MAP4K1 (0.78) | MAP4K1TNIKMAP3K11PIK3CGSGK1 | |
| SCHEMBL28600308 | 0.82 | MAP4K1 (0.61) | MAP4K1TNIKPAK1PKN1MAP3K11 | |
| SCHEMBL28596016 | 0.80 | MAP4K1 (0.52) | MAP4K1PAK1PKN1MAP3K11PIK3CG | |
| SCHEMBL21593027 | 0.80 | MAP4K1 (0.59) | MAP4K1TNIKMAP3K11PIK3CGSGK1 | |
| SCHEMBL28917806 | 0.80 | MAP4K1 (0.58) | MAP4K1TNIKPAK1PKN1MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |