Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597204 | 0.87 | GSK3B (0.56) | GSK3BABL1GSK3APIK3C3MAPK8 | |
| SCHEMBL28599044 | 0.87 | GSK3B (0.51) | GSK3BABL1PIK3C3MAPK8MAPK10 | |
| SCHEMBL28611097 | 0.86 | GSK3B (0.58) | GSK3BMAPTMAPK8MAPK10MAPK14 | |
| SCHEMBL28598189 | 0.85 | GSK3B (0.49) | GSK3BPIK3C3MAPK8MAPK10MAPK14 | |
| SCHEMBL28606595 | 0.85 | GSK3B (0.54) | GSK3BABL1MAPK8MAPK10MAPK14 | |
| SCHEMBL28599037 | 0.84 | ABL1 (0.52) | GSK3BABL1GSK3APIK3C3MAPK8 | |
| SCHEMBL28606578 | 0.84 | ABL1 (0.49) | GSK3BABL1PIK3C3MAPT | |
| SCHEMBL29083262 | 0.84 | GSK3B (0.52) | GSK3BPIK3C3MAPK14 | |
| SCHEMBL28599038 | 0.83 | GSK3B (0.48) | GSK3BGSK3APIK3C3MAPK8MAPK10 | |
| SCHEMBL28602355 | 0.82 | GSK3B (0.57) | GSK3BABL1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072552-B | Beta-carboline GSK3 beta/DYRK 1A dual inhibitor, preparation method thereof and application thereof in resisting Alzheimer disease | 中国人民解放军北部战区总医院 | 2022-11-04 | — | — | CN | disclosed |
| CN-113072552-A | Beta-carboline GSK3 beta/DYRK 1A dual inhibitor, preparation method thereof and application thereof in resisting Alzheimer disease | 中国人民解放军北部战区总医院 | 2021-07-06 | — | — | CN | disclosed |