Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10635301 | 0.76 | SLC22A6 (0.40) | TDP1SMN1; SMN2HMGCRCHRM1TBXA2R | |
| SCHEMBL11720071 | 0.76 | TDP1 (0.56) | TDP1SMN1; SMN2HMGCRCHRM1TBXA2R | |
| SCHEMBL8877734 | 0.74 | TDP1 (0.54) | TDP1SMN1; SMN2HMGCRCHRM1TBXA2R | |
| SCHEMBL554957 | 0.74 | TDP1 (0.68) | TDP1SMN1; SMN2ADRA1ASLC22A6SLC1A3 | |
| SCHEMBL5514949 | 0.74 | TDP1 (0.68) | TDP1SMN1; SMN2ADRA1ASLC22A6SLC1A3 | |
| SCHEMBL14803500 | 0.74 | TDP1 (0.68) | TDP1SMN1; SMN2ADRA1ASLC22A6SLC1A3 | |
| SCHEMBL22151 | 0.72 | TDP1 (1.00) | TDP1SMN1; SMN2TSHRSLC22A6LMNA | |
| SCHEMBL17517216 | 0.72 | TDP1 (1.00) | TDP1SMN1; SMN2TSHRSLC22A6LMNA | |
| SCHEMBL16925719 | 0.72 | TDP1 (1.00) | TDP1SMN1; SMN2TSHRSLC22A6LMNA | |
| SCHEMBL165643 | 0.72 | TDP1 (1.00) | TDP1SMN1; SMN2TSHRSLC22A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112805000-A | 2-arylbenzimidazoles as PPARGC1A activators for the treatment of neurodegenerative diseases | 小利兰·斯坦福大学董事会 | 2021-05-14 | — | — | CN | disclosed |