Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.52 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK3 | P52333 | 8/20 | 0.50 |
| ▸ | TYK2 | P29597 | 6/20 | 0.50 |
| ▸ | STAT3 | P40763 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28605522 | 0.88 | JAK3 (0.47) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL28612508 | 0.88 | FLT4 (0.49) | JAK1JAK2JAK3FLT4KDR | |
| SCHEMBL30956392 | 0.86 | DDR2 (0.46) | JAK1JAK2JAK3TYK2FLT4 | |
| SCHEMBL28598992 | 0.85 | IGF1R (0.54) | FLT4CDK2CDK7CDK9CDK8 | |
| SCHEMBL28603799 | 0.84 | IGF1R (0.46) | JAK1JAK2JAK3FLT4KDR | |
| SCHEMBL30956586 | 0.83 | JAK1 (0.60) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL22097761 | 0.83 | JAK2 (0.54) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL22089670 | 0.83 | JAK2 (0.54) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL22097798 | 0.83 | JAK2 (0.54) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL29942043 | 0.83 | JAK2 (0.54) | JAK1JAK2JAK3TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |