Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 20/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31275853 | 1.00 | RET (0.57) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL28601250 | 1.00 | RET (0.57) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL21744883 | 0.91 | RET (0.56) | RET | |
| SCHEMBL21744642 | 0.91 | RET (0.56) | RET | |
| SCHEMBL21744948 | 0.91 | RET (0.56) | RET | |
| SCHEMBL28607601 | 0.91 | RET (0.53) | RET | |
| SCHEMBL31276018 | 0.91 | RET (0.53) | RET | |
| SCHEMBL21744874 | 0.88 | RET (0.53) | RET | |
| SCHEMBL21744640 | 0.86 | RET (0.56) | RETJAK2FLT3 | |
| SCHEMBL31275835 | 0.86 | RET (0.58) | RETJAK2FLT3KIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-A | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2021-07-20 | — | — | CN | disclosed |