Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31275960 | 1.00 | RET (0.51) | RETMEN1KMT2AATMJAK2 | |
| SCHEMBL31275897 | 0.89 | RET (0.51) | RETNTRK1 | |
| SCHEMBL28609265 | 0.89 | RET (0.51) | RETNTRK1 | |
| SCHEMBL28622793 | 0.87 | RET (0.50) | RETNTRK1 | |
| SCHEMBL28618714 | 0.87 | RET (0.54) | RET | |
| SCHEMBL31275855 | 0.87 | RET (0.54) | RET | |
| SCHEMBL31275271 | 0.84 | RET (0.49) | RET | |
| SCHEMBL28618635 | 0.84 | RET (0.49) | RET | |
| SCHEMBL24409390 | 0.84 | RET (0.53) | RET | |
| SCHEMBL28601255 | 0.82 | RET (0.63) | RETJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-A | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2021-07-20 | — | — | CN | disclosed |