Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 6/20 | 0.43 |
| ▸ | TYK2 | P29597 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089934 | 1.00 | AURKA (0.44) | AURKALIMK1AURKBJAK2JAK3 | |
| SCHEMBL22098071 | 0.91 | JAK2 (0.50) | JAK2JAK3JAK1FLT3TYK2 | |
| SCHEMBL22097824 | 0.90 | MAPK1 (0.47) | AURKBJAK2JAK3JAK1FLT4 | |
| SCHEMBL29941775 | 0.90 | MAPK1 (0.47) | AURKBJAK2JAK3JAK1FLT4 | |
| SCHEMBL22097850 | 0.90 | MAPK1 (0.47) | AURKBJAK2JAK3JAK1FLT4 | |
| SCHEMBL28612309 | 0.90 | MAPK1 (0.47) | AURKBJAK2JAK3JAK1FLT4 | |
| SCHEMBL22098067 | 0.90 | JAK2 (0.43) | AURKALIMK1AURKBJAK2JAK3 | |
| SCHEMBL28603999 | 0.90 | PAK1 (0.47) | AURKALIMK1AURKBJAK2JAK3 | |
| SCHEMBL22097935 | 0.88 | HDAC3 (0.48) | AURKBJAK2JAK3JAK1FLT3 | |
| SCHEMBL29249070 | 0.88 | HDAC3 (0.48) | AURKBJAK2JAK3JAK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |