Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.54 |
| ▸ | JAK1 | P23458 | 10/20 | 0.54 |
| ▸ | JAK2 | O60674 | 9/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089914 | 1.00 | JAK3 (0.54) | JAK3JAK1JAK2MAP3K7MAPK1 | |
| SCHEMBL24852560 | 0.94 | JAK2 (0.50) | JAK3JAK1JAK2CDK1CDK2 | |
| SCHEMBL27171225 | 0.94 | JAK2 (0.50) | JAK3JAK1JAK2CDK1CDK2 | |
| SCHEMBL22089906 | 0.94 | JAK2 (0.50) | JAK3JAK1JAK2CDK1CDK2 | |
| SCHEMBL22089943 | 0.92 | JAK3 (0.54) | JAK3JAK1JAK2TYK2TBK1 | |
| SCHEMBL29941682 | 0.92 | JAK3 (0.54) | JAK3JAK1JAK2TYK2TBK1 | |
| SCHEMBL27171237 | 0.92 | JAK3 (0.54) | JAK3JAK1JAK2TYK2TBK1 | |
| SCHEMBL29942279 | 0.92 | JAK3 (0.54) | JAK3JAK1JAK2TYK2TBK1 | |
| SCHEMBL22097689 | 0.92 | JAK3 (0.54) | JAK3JAK1JAK2TYK2TBK1 | |
| SCHEMBL22089915 | 0.91 | FLT4 (0.52) | JAK3JAK1JAK2CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |