Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 18/20 | 0.44 |
| ▸ | JAK1 | P23458 | 18/20 | 0.44 |
| ▸ | TYK2 | P29597 | 18/20 | 0.44 |
| ▸ | JAK3 | P52333 | 18/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28602275 | 1.00 | KMT2A (0.46) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL22121416 | 0.88 | KMT2A (0.57) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL22121411 | 0.87 | KMT2A (0.52) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL22151391 | 0.82 | KMT2A (0.49) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL28752004 | 0.81 | STING1 (0.42) | — | |
| SCHEMBL29689171 | 0.81 | STING1 (0.42) | — | |
| SCHEMBL28752005 | 0.81 | STING1 (0.42) | — | |
| SCHEMBL22937441 | 0.81 | STING1 (0.50) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29689511 | 0.81 | STING1 (0.50) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28751947 | 0.81 | STING1 (0.50) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113549110-A | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-109608443-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109071514-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-06 | — | — | CN | disclosed |