Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 5/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569003 | 0.94 | SERPINE1 (0.43) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL25189025 | 0.86 | SYK (0.43) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL10029064 | 0.86 | SYK (0.43) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL18361449 | 0.86 | SYK (0.43) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL15876421 | 0.85 | SERPINE1 (0.40) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL10197290 | 0.85 | SERPINE1 (0.40) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL26774025 | 0.85 | SERPINE1 (0.40) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL23674564 | 0.84 | SERPINE1 (0.41) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL14726004 | 0.84 | TDP1 (0.43) | MEN1GAAKMT2ASYKSERPINE1 | |
| SCHEMBL23792183 | 0.82 | SERPINE1 (0.38) | MEN1GAAKMT2ASYKSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155775-A2 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | Mpex Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141010-A2 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |