Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857470 | 0.92 | MAPT (0.46) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2859466 | 0.91 | MAPT (0.46) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2858174 | 0.90 | MAPT (0.46) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2856888 | 0.90 | MAPT (0.44) | MAPTKMT2ALMNAMAPK1KEAP1 | |
| SCHEMBL2854223 | 0.90 | MAPT (0.43) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2855798 | 0.89 | MAPT (0.45) | MAPTMEN1KMT2ALMNAKEAP1 | |
| SCHEMBL2857207 | 0.89 | MAPT (0.43) | MAPTLMNAMAPK1KEAP1NFE2L2 | |
| SCHEMBL2856561 | 0.88 | MAPT (0.49) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2857164 | 0.87 | MAPT (0.46) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL2855767 | 0.87 | P2RX1 (0.47) | MAPTMEN1KMT2AKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |