Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.54 |
| ▸ | JAK2 | O60674 | 14/20 | 0.54 |
| ▸ | JAK1 | P23458 | 13/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941580 | 1.00 | JAK3 (0.54) | JAK3JAK2JAK1TYK2TBK1 | |
| SCHEMBL22089930 | 1.00 | JAK3 (0.54) | JAK3JAK2JAK1TYK2TBK1 | |
| SCHEMBL29942144 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1TYK2DDR2 | |
| SCHEMBL22089666 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1TYK2DDR2 | |
| SCHEMBL28611306 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1TYK2DDR2 | |
| SCHEMBL22089918 | 0.92 | JAK3 (0.54) | JAK3JAK2JAK1TYK2TBK1 | |
| SCHEMBL27171235 | 0.92 | JAK3 (0.54) | JAK3JAK2JAK1TYK2TBK1 | |
| SCHEMBL22097858 | 0.92 | JAK2 (0.47) | JAK3JAK2JAK1TBK1DDR2 | |
| SCHEMBL29248984 | 0.92 | JAK2 (0.47) | JAK3JAK2JAK1TBK1DDR2 | |
| SCHEMBL29941867 | 0.92 | JAK2 (0.47) | JAK3JAK2JAK1TBK1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |