Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TKT | P29401 | 5/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19441154 | 0.84 | GRM2 (0.33) | KDM4EGRM2 | |
| SCHEMBL2171192 | 0.79 | — | — | |
| SCHEMBL423180 | 0.77 | NPC1 (0.41) | TDP1CA2KDM4EALDH1A1MEN1 | |
| SCHEMBL1120595 | 0.75 | TDP1 (0.39) | TDP1MEN1KMT2A | |
| SCHEMBL10060439 | 0.75 | KDM4E (0.40) | TDP1CA2KDM4EALDH1A1MEN1 | |
| SCHEMBL24669627 | 0.75 | TDP1 (0.39) | TDP1CA2KDM4EALDH1A1MEN1 | |
| SCHEMBL2172820 | 0.75 | TAAR1 (0.46) | TDP1KDM4EALDH1A1BACE1 | |
| SCHEMBL16471442 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9889512 | 0.75 | PPARA (0.41) | TDP1CA2CYP4F2CYP4A11 | |
| SCHEMBL4353619 | 0.75 | TSHR (0.53) | TDP1CA2KDM4ETKTCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139334-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-2136639-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008130481-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008123963-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| EP-0502524-B1 | Microbiological process for terminal hydroxylation of ethyl-groups on aromatic 5- or 6-membered heterocycles | LONZA AG (CH) | 1996-05-15 | — | — | EP | disclosed |
| US-5326752-A | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors | GLYCOMED INCORPORATED (US) | 1994-07-05 | — | — | US | disclosed |
| US-5306625-A | Using microorganism containing genes of Pseudomonas plasmid | LONZA LTD. (CH) | 1994-04-26 | — | — | US | disclosed |
| EP-0502524-A1 | Microbiological process for terminal hydroxylation of ethyl-groups on aromatic 5- or 6-membered heterocycles | LONZA AG (CH) | 1992-09-09 | — | — | EP | disclosed |