Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 18/20 | 0.51 |
| ▸ | AKT1 | P31749 | 18/20 | 0.51 |
| ▸ | AKT2 | P31751 | 13/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | PRKCB | P05771 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288501 | 0.83 | AKT1 (0.58) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL19283120 | 0.82 | AKT1 (0.34) | AKT3AKT1AKT2 | |
| SCHEMBL25403174 | 0.76 | AKT3 (0.64) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL22308404 | 0.76 | AKT3 (0.56) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL25403166 | 0.76 | AKT3 (0.64) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL24085581 | 0.76 | AKT3 (0.56) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL19580081 | 0.76 | AKT1 (0.47) | AKT3AKT1AKT2 | |
| SCHEMBL24035309 | 0.75 | AKT1 (0.50) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL22308403 | 0.73 | AKT1 (0.50) | AKT3AKT1AKT2CYP3A4CYP1A2 | |
| SCHEMBL22307580 | 0.73 | AKT1 (0.50) | AKT3AKT1AKT2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485276-B | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117964620-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-113272304-B | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115485276-A | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-113272304-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2021-08-17 | — | — | CN | disclosed |