Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.57 |
| ▸ | SYK | P43405 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.51 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390857 | 1.00 | IGF1R (0.57) | IGF1RSYKMAPTMAPK1AHR | |
| SCHEMBL29173352 | 0.81 | SYK (0.53) | IGF1RSYKZAP70JAK2AURKA | |
| SCHEMBL30205943 | 0.81 | SYK (0.53) | IGF1RSYKZAP70JAK2AURKA | |
| SCHEMBL11346255 | 0.78 | IGF1R (0.69) | IGF1RSYKMAPTMAPK1PLK4 | |
| SCHEMBL30206112 | 0.77 | IGF1R (0.49) | IGF1RSYKMAPTMAPK1AHR | |
| SCHEMBL29173588 | 0.77 | IGF1R (0.49) | IGF1RSYKMAPTMAPK1AHR | |
| SCHEMBL18830272 | 0.75 | MAPT (0.58) | IGF1RSYKMAPTMAPK1TTBK1 | |
| SCHEMBL20005722 | 0.74 | AURKA (0.65) | IGF1RSYKJAK2AURKACD63 | |
| SCHEMBL20957578 | 0.74 | BTK (0.51) | IGF1RSYKMAPTMAPK1AHR | |
| SCHEMBL173564 | 0.73 | IGF1R (0.48) | IGF1RSYKMAPTMAPK1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164476-A | Small molecule inhibitor of DYRK1/CLK and application thereof | 代表亚利桑那大学的亚利桑那校董会 | 2021-07-23 | — | — | CN | disclosed |