SCHEMBL28610840

SCHEMBL28610840

Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCSCC2)n1

nearest known ligand 0.91

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 20/20 0.91
BRAF P15056 20/20 0.91

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28619677 1.00 RAF1 (0.91) RAF1BRAF
SCHEMBL16037859 0.95 RAF1 (1.00) RAF1BRAF
SCHEMBL28621834 0.94 RAF1 (0.91) RAF1BRAF
SCHEMBL28921062 0.94 RAF1 (0.91) RAF1BRAF
SCHEMBL16035248 0.92 RAF1 (1.00) RAF1BRAF
SCHEMBL16036209 0.90 RAF1 (1.00) RAF1BRAF
SCHEMBL16035976 0.90 RAF1 (1.00) RAF1BRAF
SCHEMBL16035973 0.90 RAF1 (0.89) RAF1BRAF
SCHEMBL16036208 0.90 RAF1 (0.89) RAF1BRAF
SCHEMBL16121705 0.89 RAF1 (1.00) RAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108467369-B Biaryl amide compounds as kinase inhibitors 诺华股份有限公司 2021-08-20 CN disclosed