Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089903 | 1.00 | JAK3 (0.47) | JAK3JAK2JAK1DDR2FLT4 | |
| SCHEMBL29942016 | 1.00 | JAK3 (0.47) | JAK3JAK2JAK1DDR2FLT4 | |
| SCHEMBL28611306 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1DDR2KDR | |
| SCHEMBL22089666 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1DDR2KDR | |
| SCHEMBL29942144 | 0.95 | JAK3 (0.49) | JAK3JAK2JAK1DDR2KDR | |
| SCHEMBL22097838 | 0.94 | JAK3 (0.46) | JAK3JAK2JAK1DDR2FLT4 | |
| SCHEMBL29249000 | 0.94 | JAK3 (0.46) | JAK3JAK2JAK1DDR2FLT4 | |
| SCHEMBL28605842 | 0.92 | DDR2 (0.47) | JAK3JAK1DDR2FLT4NUAK1 | |
| SCHEMBL22089916 | 0.92 | FLT4 (0.51) | JAK3JAK2JAK1DDR2FLT4 | |
| SCHEMBL28617756 | 0.92 | FLT4 (0.51) | JAK3JAK2JAK1DDR2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |