Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oseltamivir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | NEU1 | Q99519 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oseltamivir SCHEMBL15912673 | 0.99 | MEN1 (0.81) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL8730 | 0.99 | MEN1 (0.81) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL455879 | 0.99 | MEN1 (0.81) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL29085770 | 0.99 | MEN1 (0.81) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL18117995 | 0.99 | MEN1 (0.81) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL28487532 | 0.96 | MEN1 (0.86) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL28299940 | 0.95 | MEN1 (0.75) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL14283136 | 0.95 | MEN1 (0.88) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL125557 | 0.95 | MEN1 (0.88) | MEN1LMNACYP3A4KMT2ANEU1 | |
| Oseltamivir SCHEMBL14775954 | 0.95 | MEN1 (0.88) | MEN1LMNACYP3A4KMT2ANEU1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113277957-A | Preparation method of oseltamivir phosphate key intermediate hydrochloride | 弘健制药(上海)有限公司 | 2021-08-20 | — | — | CN | claimed |
| CN-113307744-A | Preparation method of oseltamivir phosphate | 弘健制药(上海)有限公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-113277957-A | Preparation method of oseltamivir phosphate key intermediate hydrochloride | 弘健制药(上海)有限公司 | 2021-08-20 | — | — | CN | disclosed |