Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 10/20 | 0.44 |
| ▸ | RET | P07949 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28624033 | 0.90 | PTPN11 (0.52) | PTPN11RETKCNH2HDAC3HDAC4 | |
| SCHEMBL30809727 | 0.87 | PTPN11 (0.52) | PTPN11KCNH2HDAC3HDAC4HDAC1 | |
| SCHEMBL28518407 | 0.87 | PTPN11 (0.52) | PTPN11KCNH2HDAC3HDAC4HDAC1 | |
| SCHEMBL28612011 | 0.86 | PTPN11 (0.49) | PTPN11RETKCNH2HDAC3HDAC4 | |
| SCHEMBL22049000 | 0.86 | PTPN11 (0.56) | PTPN11RET | |
| SCHEMBL28610638 | 0.85 | PTPN11 (0.49) | PTPN11RETKCNH2HDAC3HDAC4 | |
| SCHEMBL28624621 | 0.83 | PTPN11 (0.46) | PTPN11KCNH2 | |
| SCHEMBL28612023 | 0.83 | RET (0.46) | PTPN11RET | |
| SCHEMBL19641030 | 0.83 | PTPN11 (0.48) | PTPN11KCNH2 | |
| SCHEMBL19641300 | 0.82 | PTPN11 (0.47) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475531-B | Heterocyclic inhibitors of PTPN11 | 得克萨斯州立大学董事会 | 2021-08-17 | — | — | CN | disclosed |