Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 12/20 | 0.56 |
| ▸ | AKT1 | P31749 | 11/20 | 0.56 |
| ▸ | AKT2 | P31751 | 8/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24085581 | 0.83 | AKT3 (0.56) | AKT3AKT1AKT2KITCYP1A2 | |
| SCHEMBL22308404 | 0.83 | AKT3 (0.56) | AKT3AKT1AKT2KITCYP1A2 | |
| SCHEMBL2798957 | 0.80 | KIT (0.50) | AKT3AKT1AKT2KITCYP1A2 | |
| SCHEMBL22308123 | 0.80 | AKT3 (0.59) | AKT3AKT1AKT2KITCYP1A2 | |
| SCHEMBL24410911 | 0.78 | AKT1 (0.51) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL22308708 | 0.77 | AKT1 (0.56) | AKT3AKT1AKT2KITCNR1 | |
| SCHEMBL24410917 | 0.77 | AKT3 (0.71) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL1300410 | 0.77 | AKT1 (0.54) | AKT1KITCNR1CNR2MAP4K4 | |
| SCHEMBL192015 | 0.75 | KIT (0.48) | KITCNR1CNR2MAP4K4GPR119 | |
| SCHEMBL192014 | 0.75 | KIT (0.48) | KITCNR1CNR2MAP4K4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485276-B | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117964620-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-113272304-B | AKT inhibitors | 南京正大天晴制药有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115485276-A | Deuterated AKT kinase inhibitors | 南京正大天晴制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-113272304-A | AKT inhibitors | 南京正大天晴制药有限公司 | 2021-08-17 | — | — | CN | disclosed |