Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630058 | 1.00 | JAK1 (0.62) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385471 | 0.82 | JAK1 (0.65) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2295441 | 0.82 | JAK1 (0.65) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL24188841 | 0.81 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2290529 | 0.81 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL24188718 | 0.81 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL30622212 | 0.81 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL13823479 | 0.80 | JAK1 (0.73) | JAK1JAK2AURKAPRKCAKDR | |
| Trifluoroacetic Acid SCHEMBL30622151 | 0.79 | JAK1 (0.64) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL24188837 | 0.77 | JAK1 (0.87) | JAK1JAK2AURKAPRKCAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396150-A | Tricyclic JANUS kinase 1 inhibitors, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2021-09-14 | — | — | CN | disclosed |