SCHEMBL28617419

SCHEMBL28617419

N#Cc1ccc(N(Cc2ccc(C#N)c(F)c2)n2cnnc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 20/20 0.78
STS P08842 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28975491 0.91 CYP19A1 (0.77) CYP19A1STS
SCHEMBL3237797 0.88 CYP19A1 (1.00) CYP19A1STS
SCHEMBL2060145 0.85 CYP19A1 (1.00) CYP19A1STS
SCHEMBL8446302 0.85 CYP19A1 (0.86) CYP19A1STS
SCHEMBL8445536 0.84 CYP19A1 (0.76) CYP19A1STS
SCHEMBL2700646 0.82 CYP19A1 (0.76) CYP19A1STS
SCHEMBL13292452 0.81 CYP19A1 (0.82) CYP19A1
SCHEMBL8444063 0.81 CYP19A1 (0.80) CYP19A1STS
SCHEMBL13303284 0.81 CYP19A1 (0.67) CYP19A1STS
SCHEMBL3229745 0.81 CYP19A1 (1.00) CYP19A1STS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387894-A 1-N-benzene acetonitrile amido-triazole and pyrimidine derivative, preparation method and application thereof 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 2021-09-14 CN claimed
CN-113387894-B 1-N-benzene acetonitrile amido-triazole and pyrimidine derivative, preparation method and application thereof 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 2023-02-24 CN disclosed
CN-113387894-A 1-N-benzene acetonitrile amido-triazole and pyrimidine derivative, preparation method and application thereof 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 2021-09-14 CN disclosed