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Sugi Predict / Compounds / SCHEMBL28617510

SCHEMBL28617510

SCHEMBL28617510

COC(=O)c1cc(COC2CCCCO2)cc(NC(=O)c2cn(C(C)=O)c3ccccc23)c1

nearest known ligand 0.86

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CREBBP Q92793 20/20 0.86
▸ EP300 Q09472 3/20 0.86
▸ TRIM24 O15164 1/20 0.47
▸ BRD4 O60885 1/20 0.47
▸ BAZ2B Q9UIF8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28620674 0.84 CREBBP (0.62) CREBBPEP300TRIM24BRD4BAZ2B
SCHEMBL28616565 0.83 CREBBP (0.77) CREBBPEP300
SCHEMBL28921610 0.82 CREBBP (0.72) CREBBPEP300TRIM24BRD4BAZ2B
SCHEMBL29058117 0.82 CREBBP (0.76) CREBBPEP300
SCHEMBL28617942 0.81 CREBBP (0.63) CREBBPEP300TRIM24BRD4BAZ2B
SCHEMBL4310575 0.79 CREBBP (0.53) CREBBPEP300
SCHEMBL29058136 0.78 CREBBP (0.72) CREBBPEP300
SCHEMBL28612566 0.77 CREBBP (0.66) CREBBPEP300TRIM24BRD4BAZ2B
SCHEMBL28614727 0.77 CREBBP (0.80) CREBBPEP300TRIM24BRD4BAZ2B
SCHEMBL2529947 0.76 CREBBP (0.53) CREBBPEP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113321640-B Indole compound and application thereof 中国科学院广州生物医药与健康研究院 2023-06-09 — — CN disclosed
CN-109111427-B Indole compound and application thereof 中国科学院广州生物医药与健康研究院 2023-06-02 — — CN disclosed
CN-113321640-A Indole compound and application thereof 中国科学院广州生物医药与健康研究院 2021-08-31 — — CN disclosed