Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.38 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.38 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10861779 | 1.00 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| Bromide SCHEMBL28663439 | 1.00 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| Bromide SCHEMBL28490601 | 1.00 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL27520398 | 0.98 | EPHX1 (0.44) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL27630557 | 0.98 | EPHX1 (0.44) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL8871029 | 0.98 | EPHX1 (0.44) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL8871460 | 0.98 | EPHX1 (0.44) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| Hydrochloric Acid SCHEMBL27868020 | 0.95 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| Water SCHEMBL16411956 | 0.95 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA | |
| Hydrochloric Acid SCHEMBL27884517 | 0.95 | EPHX1 (0.42) | EPHX1ALDH1A1KDM4ETSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989509-B | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-10-18 | — | — | CN | claimed |
| CN-114989509-A | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-113248839-B | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-113248839-A | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2021-08-13 | — | — | CN | claimed |
| CN-114989509-B | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114989509-A | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-113248839-B | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-113248839-A | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2021-08-13 | — | — | CN | disclosed |