Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 3/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18107777 | 0.80 | BRD4 (0.47) | MIFPBRM1CYP3A4MEN1KMT2A | |
| SCHEMBL2765998 | 0.78 | MIF (0.70) | MIFCA2CA5AHDAC3HDAC1 | |
| SCHEMBL26938963 | 0.76 | MIF (0.67) | MIFALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL3549595 | 0.76 | MIF (0.46) | MIFDRD2DRD1DRD5DRD3 | |
| SCHEMBL10075481 | 0.75 | BRD4 (0.46) | ALDH1A1MAOAMAOBCYP3A4MEN1 | |
| SCHEMBL2765855 | 0.75 | MIF (0.63) | MIFKDM4EALDH1A1HDAC3HDAC1 | |
| SCHEMBL2766364 | 0.74 | MIF (0.65) | MIFKDM4EALDH1A1HDAC3HDAC1 | |
| SCHEMBL2766991 | 0.73 | MIF (0.74) | MIFKDM4EALDH1A1HDAC3HDAC1 | |
| SCHEMBL3625289 | 0.73 | MIF (0.54) | MIFKDM4EALDH1A1HDAC3HDAC1 | |
| SCHEMBL2765851 | 0.73 | MIF (0.45) | MIFCHRNA7MAOAMAOBESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113234079-B | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113234079-A | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2021-08-10 | — | — | CN | disclosed |