Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 8/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 8/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862047 | 1.00 | S1PR4 (0.53) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL2861143 | 0.86 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL4493249 | 0.86 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL2493402 | 0.86 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL21820688 | 0.86 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| Hydrochloric Acid SCHEMBL2161847 | 0.85 | PSEN1 (0.44) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL8267837 | 0.85 | S1PR4 (0.44) | S1PR4S1PR1S1PR5S1PR3 | |
| Hydrochloric Acid SCHEMBL2874986 | 0.85 | PSEN1 (0.44) | S1PR4S1PR1S1PR5S1PR3PSEN1 | |
| SCHEMBL27798006 | 0.80 | P2RY14 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Acetic Acid SCHEMBL9894871 | 0.76 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |