Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 19/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 19/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282494 | 0.78 | CRBN (0.67) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18509320 | 0.78 | CRBN (0.67) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18945869 | 0.78 | CRBN (0.67) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18945874 | 0.76 | CRBN (0.64) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL26672049 | 0.76 | CRBN (0.64) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL283372 | 0.76 | CRBN (0.64) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL26269147 | 0.76 | CRBN (0.60) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18596192 | 0.71 | CRBN (0.74) | DDB1CRBNIKZF3ALDH1A1CHRM2 | |
| SCHEMBL19954297 | 0.71 | CRBN (0.74) | DDB1CRBNIKZF3ALDH1A1CHRM2 | |
| SCHEMBL20812400 | 0.70 | CRBN (1.00) | DDB1CRBNIKZF3ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-03-14 | — | — | EP | disclosed |