Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2864115 | 0.91 | KDR (0.71) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2881203 | 0.89 | KDR (0.69) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2864135 | 0.88 | KDR (0.68) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2855759 | 0.88 | KDR (0.76) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2859425 | 0.86 | KDR (0.71) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL3913172 | 0.85 | KDR (0.68) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2862543 | 0.83 | KDR (0.77) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2858208 | 0.83 | KDR (0.67) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2859629 | 0.83 | KDR (0.67) | KDRPDGFRBKITFLT1KCNH2 | |
| SCHEMBL2861807 | 0.82 | KDR (0.66) | KDRPDGFRBKITFLT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513818-B1 | HETEROCYCLIC INHIBITORS OF VEGFR-2 KINASES | BRISTOL MYERS SQUIBB CO (US) | 2010-01-20 | — | — | EP | disclosed |
| US-7084160-B2 | Heterocyclic inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-01 | — | — | US | disclosed |