SCHEMBL28627963

COc1ccc(C(OC[C@@H]2O[C@@H](n3ccc4c(NC(=O)c5ccccc5)ncnc43)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]2CC(=O)O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	TYMP	P19971	4/20	0.40

▸	ADK	P55263	1/20	0.35

▸	PRMT5	O14744	3/20	0.35

▸	WDR77	Q9BQA1	3/20	0.35

▸	TMIGD3	P0DMS9	3/20	0.35

▸	PRMT6	Q96LA8	1/20	0.34

▸	RET	P07949	1/20	0.34

▸	KDR	P35968	1/20	0.34

▸	METTL3	Q86U44	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23023830	0.91	TYMP (0.46)	TYMPADKPRMT5WDR77METTL3
SCHEMBL18521315	0.91	TYMP (0.46)	TYMPADKPRMT5WDR77METTL3
SCHEMBL22381870	0.91	TYMP (0.46)	TYMPADKPRMT5WDR77METTL3
SCHEMBL18521074	0.91	TYMP (0.46)	TYMPADKPRMT5WDR77METTL3
SCHEMBL23023831	0.90	TYMP (0.46)	TYMPADKPRMT5WDR77METTL3
SCHEMBL23023832	0.88	TYMP (0.39)	TYMPADKPRMT5WDR77PRMT6
SCHEMBL29814359	0.88	TYMP (0.39)	TYMPADKPRMT5WDR77PRMT6
SCHEMBL28645640	0.87	TYMP (0.38)	TYMPADKPRMT5WDR77PRMT6
SCHEMBL23702464	0.87	TYMP (0.38)	TYMPADKPRMT5WDR77PRMT6
SCHEMBL23702465	0.86	TYMP (0.37)	TYMPADKPRMT5WDR77TMIGD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-109694397-B	Cyclic dinucleotide compounds, preparation method and application thereof	上海弘翊生物科技有限公司	2021-08-31	—	—	CN	disclosed