Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF1 | Q13422 | 4/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | IL1B | P01584 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25133945 | 0.89 | IKZF1 (0.52) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL29583349 | 0.89 | IKZF1 (0.52) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL19585546 | 0.89 | CRBN (0.55) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL22345865 | 0.89 | IKZF1 (0.64) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL21680538 | 0.84 | IKZF1 (0.46) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL29641009 | 0.83 | IKZF1 (0.60) | IKZF1IKZF2CRBNDDB1IKZF3 | |
| SCHEMBL20046073 | 0.83 | IKZF1 (0.60) | IKZF1IKZF2CRBNDDB1IKZF3 | |
| SCHEMBL31072991 | 0.82 | IKZF2 (0.46) | IKZF1IKZF2CRBNDDB1PDK4 | |
| SCHEMBL27223253 | 0.82 | CRBN (0.53) | IKZF1CRBNDDB1PDK4BRD4 | |
| SCHEMBL27376679 | 0.82 | CRBN (0.53) | IKZF1CRBNDDB1PDK4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113329792-A | Substituted 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2021-08-31 | — | — | CN | disclosed |