Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28628197 | 1.00 | TNK2 (0.48) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL14654048 | 0.89 | TNK2 (0.48) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL15929395 | 0.89 | TNK2 (0.48) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29926560 | 0.86 | JAK2 (0.47) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL14313020 | 0.86 | JAK2 (0.47) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL14313430 | 0.86 | JAK2 (0.47) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL14313428 | 0.86 | JAK2 (0.47) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29854457 | 0.85 | JAK2 (0.47) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL15929297 | 0.85 | IGF1R (0.51) | TNK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30898401 | 0.85 | JAK2 (0.46) | JAK2JAK1TYK2JAK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336760-B | Substituted amide derivatives, compositions and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-113493439-B | Substituted acrylamide derivative, composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-113336760-A | Substituted amide derivatives, compositions and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2021-09-03 | — | — | CN | disclosed |