Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.30 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.30 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL28868287 | 0.94 | GSR (0.38) | GSRPRCPGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL1473089 | 0.94 | GSR (0.38) | GSRPRCPGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL29151521 | 0.91 | GSR (0.36) | GSRPRCPGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL29206207 | 0.89 | MEN1 (0.40) | MEN1KMT2APRCP | |
| Arginine SCHEMBL19124293 | 0.89 | MEN1 (0.40) | MEN1KMT2APRCP | |
| Arginine SCHEMBL3195919 | 0.88 | GSR (0.33) | GSRPRCPGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28857223 | 0.88 | KMT2A (0.41) | MEN1KMT2APRCP | |
| Arginine SCHEMBL28818309 | 0.88 | GSR (0.37) | GSRPRCPGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28469088 | 0.88 | PRCP (0.35) | PRCP | |
| Arginine SCHEMBL29206209 | 0.88 | PRCP (0.35) | PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110283233-B | Cathepsin S substrate, application thereof and kit containing same | 吴永峰 | 2021-08-27 | — | — | CN | disclosed |