Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 17/20 | 0.60 |
| ▸ | EP300 | Q09472 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30394853 | 1.00 | CREBBP (0.60) | CREBBPEP300SMN1; SMN2NPC1TP53 | |
| SCHEMBL11682254 | 0.75 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1TP53MAPTRAB9A | |
| SCHEMBL28623958 | 0.75 | CREBBP (1.00) | CREBBPEP300NPC1TP53RAB9A | |
| SCHEMBL28619691 | 0.75 | TAF1 (0.67) | CREBBPEP300SMN1; SMN2NPC1TP53 | |
| SCHEMBL30393642 | 0.75 | TAF1 (0.67) | CREBBPEP300SMN1; SMN2NPC1TP53 | |
| SCHEMBL6804621 | 0.75 | SMN1; SMN2 (0.69) | CREBBPSMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL3767593 | 0.74 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1TP53MAPTRAB9A | |
| SCHEMBL6668770 | 0.74 | SMN1; SMN2 (0.65) | CREBBPSMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6668625 | 0.74 | HSD17B3 (0.57) | CREBBPSMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6808893 | 0.73 | TRIM24 (0.57) | CREBBPSMN1; SMN2NPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113321640-B | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-06-09 | — | — | CN | disclosed |
| CN-109111427-B | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-06-02 | — | — | CN | disclosed |
| CN-113321640-A | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2021-08-31 | — | — | CN | disclosed |